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Stem cell\u2010based therapies, which deliver mesenchymal stem cells (MSCs) to the wound site, hold a considerable promise for endometrium regeneration. However, some notable hurdles, such as stemness loss, immunogenicity, low retention and survival rate, limit their clinical application. Evidence shows a strategy of mobilizing endogenous MSCs recruitment can overcome the traditional limitations of exogenous stem cell\u2010based therapies. Here, an acellular biomaterial named stromal derived factor\u20101 alpha (SDF\u20101<jats:italic>\u03b1<\/jats:italic>)\/E7\u2010modified collagen scaffold (CES) is explored. CES based on harnessing the innate regenerative potential of the body enables near\u2010complete endometrium regeneration and fertility restoration both in a rat endometrium acute damage model and a rat IUA model. Mechanistically, the CES implantation promotes endogenous MSCs recruitment via a macrophage\u2010coordinated strategy; then the homing MSCs exert the function of immunomodulation and altered local microenvironments toward regeneration. To conclude, CES, which can harness endogenous MSCs and overcome the traditional limitations of cell\u2010based therapies, can serve as a clinically feasible and cell\u2010free strategy with high therapeutic efficiency for IUA treatment.<\/jats:p>","DOI":"10.1002\/adhm.202201680","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T20:18:48Z","timestamp":1662063528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["An Acellular Scaffold Facilitates Endometrial Regeneration and Fertility Restoration via Recruiting Endogenous Mesenchymal Stem Cells"],"prefix":"10.1002","volume":"11","author":[{"given":"Liaobing","family":"Xin","sequence":"first","affiliation":[{"name":"Assisted Reproduction Unit Department of Obstetrics and Gynecology Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou 310016 China"},{"name":"Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province. 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