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It is a critical issue to choose appropriate biomimetic conditions to evaluate biocompatibility. Compared with other candidates for biodegradable stents, iron\u2010based materials are of high mechanical strength, yet have raised more concerns about biodegradability and biocompatibility. Herein, a metal\u2010polymer composite strategy is applied to accelerate the degradation of iron\u2010based stents in vitro and in a porcine model. Furthermore, it is found that serum, the main environment of vascular stents, ensured the safety of iron corrosion through its antioxidants. This work highlights the importance of serum, particularly albumin, for an in vitro condition mimicking blood\u2010related physiological condition, when reactive oxygen species, inflammatory response, and neointimal hyperplasia are concerned. The resultant metal\u2010polymer composite stent is implanted into a patient in clinical research via interventional treatment, and the follow\u2010up confirms its safety, efficacy, and appropriate biodegradability.<\/jats:p>","DOI":"10.1002\/adhm.202201740","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T12:48:28Z","timestamp":1662209308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Biodegradable Metal\u2010Polymer Composite Stent Safe and Effective on Physiological and Serum\u2010Containing Biomimetic Conditions"],"prefix":"10.1002","volume":"11","author":[{"given":"Hongjie","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University  Shanghai 200438 P. R. 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