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Accumulating evidence suggests that continuous delivery of H<jats:sub>2<\/jats:sub>S to cancer cells for extended periods of time suppresses cancer progression. However, one major challenge in therapeutic applications of H<jats:sub>2<\/jats:sub>S is its controlled delivery. To solve this problem, polymeric micelles are developed containing H<jats:sub>2<\/jats:sub>S donating\u2010anethole dithiolethione (ADT) groups, with H<jats:sub>2<\/jats:sub>S release profiles optimal for suppressing cancer cell proliferation. The micelles release H<jats:sub>2<\/jats:sub>S upon oxidation by reactive oxygens species (ROS) that are present inside the cells. The H<jats:sub>2<\/jats:sub>S release profiles can be controlled by changing the polymer design. Furthermore, the micelles that show a moderate H<jats:sub>2<\/jats:sub>S release rate exert the strongest anti\u2010proliferative effect in human colon cancer cells in in vitro assays as well as the chick chorioallantoic membrane cancer model, while the micelles do not affect proliferation of human umbilical vein endothelial cells. This study shows the importance of fine\u2010tuning H<jats:sub>2<\/jats:sub>S release profiles using a micelle approach for realizing the full therapeutic potential of H<jats:sub>2<\/jats:sub>S in cancer treatment.<\/jats:p>","DOI":"10.1002\/adhm.202201836","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T13:13:40Z","timestamp":1670678020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Reactive Oxygen Species\u2010Triggered Hydrogen Sulfide Release and Cancer\u2010Selective Antiproliferative Effect of Anethole Dithiolethione\u2010Containing Polymeric Micelles"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-1887","authenticated-orcid":false,"given":"Andr\u00e9 J.","family":"van der Vlies","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette M.","family":"Adair","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Adair","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering The Pennsylvania State University  University Park PA 16802 USA"},{"name":"Materials Research Institute The Pennsylvania State University  University Park PA 16802 USA"},{"name":"Department of Bioengineering The Pennsylvania State University  University Park PA 16802 USA"},{"name":"Department of Pharmacology The Pennsylvania State University  Hershey PA 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-4480","authenticated-orcid":false,"given":"Enrique D.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering The Pennsylvania State University  University Park PA 16802 USA"},{"name":"Department of Chemical Engineering The Pennsylvania State University  University Park PA 16802 USA"},{"name":"Materials Research Institute The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4189-7630","authenticated-orcid":false,"given":"Urara","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2222"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908047106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00506.2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12811"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.10.134"},{"key":"e_1_2_8_6_1","volume-title":"Chemistry, Biochemistry, and Pharmacology of Hydrogen Sulfide","author":"Kida K.","year":"2015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12773"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021077"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705891104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1206-8"},{"key":"e_1_2_8_10_1","first-page":"5097","volume":"8","author":"Wang G.","year":"2015","journal-title":"Int. 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