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Here, a novel scaffold composed of silk fibroin and polypyrrole (SP50) with a typical sponge\u2010like porous structure and electrical conductivity similar to the native myocardium is developed. An electroactive engineered cardiac patch (SP50 ECP) with a certain thickness is constructed by applying electrical stimulation (ES) to the cardiomyocytes (CMs) on the scaffold. SP50 ECP can significantly express cardiac marker protein (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010actinin, Cx\u201043, and cTnT) and has better contractility and electrical coupling performance. Following in vivo transplantation, SP50 ECP shows a notable therapeutic effect in repairing infarcted myocardium. Not only can SP50 ECP effectively improves left ventricular remodeling and restore cardiac functions, such as ejection function (EF), but more importantly, improves the propagation of electrical pulses and promote the synchronous contraction of CMs in the scar area with normal myocardium, effectively reducing the susceptibility of MI rats to arrhythmias. In conclusion, this study demonstrates a facile approach to constructing electroactive ECPs based on porous conductive scaffolds and proves the therapeutic effects of ECPs in repairing the infarcted heart, which may represent a promising strategy for MI treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202201856","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T09:12:00Z","timestamp":1665652320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["A Conductive Bioengineered Cardiac Patch for Myocardial Infarction Treatment by Improving Tissue Electrical Integrity"],"prefix":"10.1002","volume":"12","author":[{"given":"Qi","family":"Yin","sequence":"first","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  Beijing 100850 P. R. 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