{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:53:47Z","timestamp":1785891227019,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272162"],"award-info":[{"award-number":["82272162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171380"],"award-info":[{"award-number":["32171380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332021067"],"award-info":[{"award-number":["3332021067"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019PT350005"],"award-info":[{"award-number":["2019PT350005"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The imaging of hydrogel scaffolds by <jats:sup>19<\/jats:sup>F magnetic resonance imaging (MRI) represents an attractive tool for straightforward and noninvasive monitoring of their morphology and in vivo fate. However, their further applications are significantly limited by a dilemma of insufficient signal resolution with low <jats:sup>19<\/jats:sup>F content, and\/or hydrophobic aggregation of fluorine moieties\u2010induced signal attenuation with high <jats:sup>19<\/jats:sup>F content. Herein, a novel label\u2010free fluorinated hydrogel (PFCB) is fabricated with high fluorine content to realize noninvasive monitoring through <jats:sup>19<\/jats:sup>F MRI under ultrahigh scanning resolution (1 mm of scanning thickness). The integration of a zwitterionic unit into each fluorine moiety completely overcame the hydrophobic aggregation\u2010induced signal attenuation, manifesting as high <jats:sup>19<\/jats:sup>F content and imaging performance. Importantly, 3D reconstruction of the PFCB hydrogel in vivo can be facilely and accurately performed with background free signals, providing detailed biological information of the implanted hydrogel. Additionally, PFCB hydrogel showed adjustable and high mechanical performance, and exhibited minimum foreign body reaction after implantation. As a proof of concept, PFCB hydrogel could be further applied as gel electrodes and wireless flexible sensors for healthcare monitoring. Overall, such label\u2010free fluorinated PFCB hydrogel is an ideal flexible scaffold for eventual clinical applications integrating <jats:sup>19<\/jats:sup>F MRI\u2010guided unequivocally 3D reconstruction and healthcare monitoring.<\/jats:p>","DOI":"10.1002\/adhm.202201894","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T04:49:48Z","timestamp":1667969388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Flexible and Zwitterionic Fluorinated Hydrogel Scaffold with High Fluorine Content for Noninvasive <sup>19<\/sup>F Magnetic Resonance Imaging under Ultrahigh Scanning Resolution"],"prefix":"10.1002","volume":"12","author":[{"given":"Zujian","family":"Feng","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University  Tianjin 300072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University  Tianjin 300072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangnian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 P. R. China"},{"name":"Key Laboratory of Innovative Cardiovascular Devices Chinese Academy of Medical Sciences  Beijing 100144 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University  Tianjin 300072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deling","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University  Tianjin 300071 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0333-0868","authenticated-orcid":false,"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 P. R. China"},{"name":"Key Laboratory of Innovative Cardiovascular Devices Chinese Academy of Medical Sciences  Beijing 100144 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 P. R. China"},{"name":"Key Laboratory of Innovative Cardiovascular Devices Chinese Academy of Medical Sciences  Beijing 100144 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01177"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba8014"},{"key":"e_1_2_8_1_4","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00595H"},{"key":"e_1_2_8_1_5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3627"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-0699-3"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2612-2"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6362"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz6694"},{"key":"e_1_2_8_2_5","doi-asserted-by":"publisher","DOI":"10.1039\/D0MH00361A"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3095"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.03.042"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00278J"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201603404"},{"key":"e_1_2_8_4_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.11.053"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.07.012"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.6b04649"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB02019D"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502232112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00632"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005657"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b02115"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120184"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b04075"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00258E"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.09.001"},{"key":"e_1_2_8_8_4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102540"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.03.070"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00812"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.8b01190"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.7b01285"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.23229"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pep2.24184"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b03764"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118633953"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2016.04.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5442"},{"key":"e_1_2_8_15_2","first-page":"553","volume":"31","author":"Zhang L.","year":"2013","journal-title":"Prilozi \u2010 Maked. Akad. Nauk. Umet., Odd. Prir.\u2010Mat. Bioteh. Nauki"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810363"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b00036"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c23810"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127500"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11782"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.006"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202201894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202201894","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202201894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:05:42Z","timestamp":1759781142000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202201894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,20]]},"references-count":44,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/adhm.202201894"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202201894","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,20]]},"assertion":[{"value":"2022-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2201894"}}