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Herein, green tea catechin (\u2212)\u2010epigallocatechin gallate (EGCG) and ferrous ions (Fe<jats:sup>2+<\/jats:sup>) are utilized to construct a nutrient carrier platform that self\u2010assembles with nutrients to form phenolic\u2010based nutrient complexes (PNCs). PNCs effectively prolong the residence and absorption time of nutrients in the intestine. Further this platform is applied to integrate full nutrient formula, an enteral nutrition (EN) preparation containing a range of full nutrient components. In an SBS rat model, the prepared phenolic\u2010based integrative nutrient complexes (PINCs) enhance nutritional status, improve anemia and immune function, as well as facilitate the growth of remaining intestinal villi and crypts, and maintain the integrity of the intestinal barrier. In addition, PINCs enable the modulation of gut microbial dysbiosis, enrich the abundance of beneficial bacteria, and have no toxic effects after the long\u2010term ingestion. These results provide a proof of principle for the use of polyphenol\u2010based nanocomplexes as EN preparation, offering a feasible strategy for both nutritional support and therapeutic perspectives for SBS treatment.<\/jats:p>","DOI":"10.1002\/adhm.202201933","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T03:26:18Z","timestamp":1667791578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Self\u2010Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-2471","authenticated-orcid":false,"given":"Zhengming","family":"Zhou","sequence":"first","affiliation":[{"name":"West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan 610041 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