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Here, copper\u2010based metal\u2010organic networks (Cu\u2010MON) are generated by one\u2010step reaction using anti\u2010inflammatory and antioxidant baicalein as organic ligand and pro\u2010angiogenic copper as metal ions. Phosphate buffered saline is required for triggering Cu\u2010MON formation, and baicalein regulates the morphology and particle size of Cu\u2010MON. Cu\u2010MON are composed of Cu\u2010baicalein complexes (82.08 wt%) and Cu<jats:sub>3<\/jats:sub>(PO<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub>\u00b73H<jats:sub>2<\/jats:sub>O (17.92 wt%), thus exhibit a variable catalase\u2010like activity against different H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> levels due to the reversible change between Cu<jats:sup>2+<\/jats:sup>\/Cu<jats:sup>1+<\/jats:sup>\/Cu<jats:sup>0<\/jats:sup> species. Intramuscular injection of Cu\u2010MON significantly increases blood flow of ischemic limb in diabetic mice, enhances the relative activities of redox\u2010related enzymes in ischemic muscle, thus effectively ameliorating the oxidative damage. Taken together, through moderate and dynamic \u201cprecise homeostasis regulation of cells,\u201d Cu\u2010MON can be an efficient therapeutic strategy for peripheral arterial disease with diabetic complications.<\/jats:p>","DOI":"10.1002\/adhm.202202010","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T08:29:12Z","timestamp":1669192152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Redox Modulatory Cu(II)\u2010Baicalein Microflowers Prepared in One Step Effectively Promote Therapeutic Angiogenesis in Diabetic Mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Kaijing","family":"Liu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"},{"name":"School of Pharmacy &amp; Pharmaceutical Science University of California Irvine  209 Steinahus Hall Irvine CA 92697\u20103958 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youlu","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Fu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 China"},{"name":"Tianjin Institutes of Health Science Chinese Academy of Medical Science and Peking Union College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houzao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing 100005 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Science and Peking Union Medical College  Beijing 100730 P. 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