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However, few shape memory sponges have fast degradable properties in order to not hinder tissue healing. In this work, based on cryopolymerization, a succinic ester\u2010based sponge (Ssponge) is fabricated using gelatin and bi\u2010polyethylene glycol\u2010succinimidyl succinate (Bi\u2010PEG\u2010SS). Compared with the commercially available gelatin sponge (Csponge), Ssponge possesses better water\/blood absorption ability and higher mechanical pressure over the surrounding tissues. Moreover, in the models of massive liver hemorrhage after transection and noncompressive liver wounds by penetration, Ssponge exhibits a better hemostasis performance than Csponge. Furthermore, in a liver regeneration model, Ssponge\u2010treated livers shows higher regeneration speed compared with Csponge, including a lower injury score, more cavity\u2010like tissues, less fibrosis and enhanced tissue regeneration. Overall, it is shown that Ssponge, with a fast degradation behavior, is not only highly efficient in stopping bleeding but also not detrimental for tissue healing, possessing promising clinical translational potential.<\/jats:p>","DOI":"10.1002\/adhm.202202122","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T09:28:58Z","timestamp":1668763738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Succinic Ester\u2010Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration"],"prefix":"10.1002","volume":"12","author":[{"given":"Ye","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Medical Engineering Department of Biophysics School of Basic Medical Sciences Health Science Center Xi'an Jiaotong University  Xi'an 710061 P. R. 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