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However, the emergence of chemo\u2010resistance and systemic side effects often seriously affects the treatment and prognosis. Herein, an intelligent nanoplatform based on dendritic mesoporous organosilica nanoparticles (DMON) is constructed. The encapsulated phase\u2010change material, 1\u2010tetradecanol (TD) can serve as a \u201cdoorkeeper\u201d and enable the responsive release of drugs based on the temperature changes. Meanwhile, polyethylene glycol (PEG) is used to improve the dispersibility and biocompatibility. Cisplatin is chosen as the model of chemotherapy drug, which is co\u2010loaded with indocyanine green (ICG) in DMON to produce DMON\u2010PEG\u2010cisplatin\/ICG\u2010TD (DPCIT). Exciting, the hyperthermia and reactive oxygen species induced by ICG under the NIR\u2010laser irradiation will initiate a phase transition of TD to release cisplatin, thus leading a combined therapy (chemo\/photothermal\/photodynamic therapy). The results indicated that under laser irradiation, DPCIT can kill cancer cells and inhibit tumor growth efficiently. In addition, the designed nanoplatform reveals minimal systemic toxicity in vivo, in contrast, the distinct liver damage can be observed by the direct treatment of cisplatin. Overall, this research may provide a general approach for the targeted delivery and controlled release of chemotherapy drugs to realize a cooperatively enhanced multimodal tumor therapy.<\/jats:p>","DOI":"10.1002\/adhm.202202245","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:23:20Z","timestamp":1668392600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Phase\u2010Change Mediated Intelligent Nanoplatform for Chemo\/Photothermal\/Photodynamic Therapy of Cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaochun","family":"Hu","sequence":"first","affiliation":[{"name":"Breast Cancer Center East Hospital Affiliated to Tongji University Tongji University School of Medicine Shanghai Key Laboratory of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University  Shanghai 200120 P. R. 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