{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:54Z","timestamp":1787314254853,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101060"],"award-info":[{"award-number":["82101060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21S31900900"],"award-info":[{"award-number":["21S31900900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["19QA1405200"],"award-info":[{"award-number":["19QA1405200"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The repair of damaged cartilage still remains a great challenge in clinic. It is demonstrated that bone marrow stromal cells (BMSCs)\u2010chondrocytes communication is of great significance for cartilage repair. Moreover, BMSCs have been confirmed to enhance biological function of chondrocytes via exosome\u2010mediated paracrine pathway. Lithium\u2010containing scaffolds have been reported to effectively promote cartilage regeneration; however, whether lithium\u2010containing biomaterial could facilitate cartilage regeneration through regulating BMSCs\u2010derived exosomes has not been illustrated. In the study, the model lithium\u2010substituted bioglass ceramic (Li\u2010BGC) is selected and regulatory effects of BMSCs\u2010derived exosomes after Li\u2010BGC treatment (Li\u2010BGC\u2010Exo) are systemically evaluated. The data reveal that Li\u2010BGC\u2010Exo notably promotes chondrogenesis, which attributes to the upregulated exosomal miR\u2010455\u20103p transfer, consequently leads to suppression of histone deacetylase 2 (HDAC2) and enhanced histone H3 acetylation in chondrocytes. Notably, BMSCs\u2010derived exosomes after LiCl\u00a0treatment\u00a0(LiCl\u2010Exo) exhibits the similar regulatory effect with Li\u2010BGC\u2010Exo, indicating that the pro\u2010chondrogenesis capability of them is mainly owing to the lithium ions. Furthermore, the in vivo study proves that LiCl\u2010Exo remarkably facilitates cartilage regeneration. The research may provide novel possibility for the intrinsic mechanism of chondrogenesis trigged by lithium\u2010containing biomaterials, and suggests that application of lithium\u2010containing scaffolds may be a promising strategy for cartilage regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202202390","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T18:59:45Z","timestamp":1673290785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lithium\u2010Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells\u2010Derived Exosomal miR\u2010455\u20103p and Histone H3 Acetylation"],"prefix":"10.1002","volume":"12","author":[{"given":"Lu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthodontics Shanghai Ninth People's Hospital Collage of Stomatology Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Shanghai Ninth People's Hospital Collage of Stomatology Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunguo","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Shanghai Ninth People's Hospital Collage of Stomatology Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengtie","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-8359","authenticated-orcid":false,"given":"Bing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Shanghai Ninth People's Hospital Collage of Stomatology Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa910"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1846"},{"key":"e_1_2_9_4_1","first-page":"2089","volume":"10","author":"He X.","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2916"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-02001-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.042"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0517"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X14666191029104249"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.02.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.11.028"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144764"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.10.038"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201701089"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.044"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0125-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq217"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22913"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38373"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328217706640"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916918"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01606-w"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00450B"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c20565"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1938752"},{"key":"e_1_2_9_28_1","first-page":"40","volume":"37","author":"Swingler T. E.","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115564"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184475"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1004-0"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.03.022"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17133"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00161"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.10.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0565-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24460-7"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.09.032"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117718"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0322-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046462"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.560117"},{"key":"e_1_2_9_44_1","first-page":"2117","volume":"41","author":"Wang P.","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.626708"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-02373-y"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13808"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.11.006"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010002"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111041"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.05.034"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.01.043"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.07.003"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.12.173"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0853-x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.06.022"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01168"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202202390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202202390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202202390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:22:13Z","timestamp":1759764133000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202202390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/adhm.202202390"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202202390","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2202390"}}