{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:55:56Z","timestamp":1787169356635,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The emergence of resistance to conventional antimalarial treatments remains a major cause for concern. New drugs that target the distinct development stages of Plasmodium parasites are required to address this risk. Herein, water\u2010soluble aggregation\u2010induced emission active cyclometalated iridium(III) polypyridyl complexes (\n                    <jats:bold>Ir1\u2013Ir12<\/jats:bold>\n                    ) are developed for the elimination of malaria parasites. Remarkably, these complexes show potent antimalarial activity in low nanomolar range against 3D7 (chloroquine and artemisinin sensitive strain), RKL9 (chloroquine resistant strain), and R539T (artemisinin resistant strains) strains of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    with faster killing rate of malaria parasites. Concomitantly, these complexes exhibit efficient in vivo antimalarial activity against both the asexual and gametocyte stages of\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    malaria parasite, suggesting promising transmission\u2010blocking potential. The complexes tend to localize into mitochondria of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    determined by image and cell\u2010based assay. The mechanistic studies reveal that these complexes exert their antimalarial activity by increasing reactive oxygen species levels and disrupting its mitochondrial membrane potential. Furthermore, the mitochondrial\u2010dependent antimalarial activity of these complexes is confirmed in yeast model. Thus, this study for the first time highlights the potential role of targeting\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    mitochondria by iridium complexes in discovering and developing the next\u2010generation antimalarial agents for treating multidrug resistant malaria parasites.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202202411","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:11:09Z","timestamp":1670994669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Development of Mitochondria Targeting AIE\u2010Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents"],"prefix":"10.1002","volume":"12","author":[{"given":"Geeta","family":"Kumari","sequence":"first","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Physical Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Kumar","family":"Sah","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Gautam","sequence":"additional","affiliation":[{"name":"School of Physical Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Saini","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi 110067 India"},{"name":"Department of Life Sciences School of Natural Sciences Shiv Nadar University  Gautam Budhha Nagar Uttar Pradesh 201314 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashima","family":"Gupta","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh K.","family":"Kushawaha","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailja","family":"Singh","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-1269","authenticated-orcid":false,"given":"Pijus K.","family":"Sasmal","sequence":"additional","affiliation":[{"name":"School of Physical Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"World Health Organization World Malaria Report 2020 Geneva https:\/\/cdn.who.int\/media\/docs\/default\u2010source\/malaria\/world\u2010malaria\u2010reports\/9789240015791\u2010double\u2010page\u2010view.pdf(accessed: August2020)."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.08.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr3001252"},{"key":"e_1_2_9_4_1","volume-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.193"},{"key":"e_1_2_9_6_1","volume-title":"Global Plan for Artemisinin Resistance Containment (GPARC)","author":"World Health Organization","year":"2011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.328.5980.844"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850515)55:10<2303::AID-CNCR2820551002>3.0.CO;2-L"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527633104.ch12"},{"key":"e_1_2_9_11_1","first-page":"279","volume-title":"Metal Ions in Biological Systems, Vol. 41: Metal Ions and Their Complexes in Medication","author":"Messori L.","year":"2004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400460s"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC06037B"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sc22349c"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41143e"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00597"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201601149"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00271"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04082G"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2021.03.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt12247b"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00338"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225276"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303690"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026614666140808122329"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1511-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301422h"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-471"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.5b00458"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00196G"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201801090"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.11.018"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.019"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112694"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT01935F"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2020.120175"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23919-x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EI10-0013-2016"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.7"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.91"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.96"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochemrev.2019.100317"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.10.022"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC04175B"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1DT00592H"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c11161"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC02901A"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.202000754"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT00180E"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA10161A"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202004776"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b03723"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2019.117335"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00956"},{"key":"e_1_2_9_56_1","volume":"183","author":"Jiang X.","year":"2020","journal-title":"Cell"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.088"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.11.009"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030949"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22039"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6DT03328H"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2011.02.001"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-240"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-1-1"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121872"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.06.026"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00256"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830010410"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(70)90033-1"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.2307\/3280287"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6960-9_9"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.185"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012646"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-190"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1416"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202202411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202202411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202202411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:32:51Z","timestamp":1759750371000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202202411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,25]]},"references-count":77,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/adhm.202202411"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202202411","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,25]]},"assertion":[{"value":"2022-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2202411"}}