{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:56:49Z","timestamp":1790287009178,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973081"],"award-info":[{"award-number":["51973081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urinary tract infections caused by urinary catheter implantations are becoming more serious. Therefore, the construction of a responsive antibacterial biomaterial that can not only provide biocompatible conditions, but also effectively prevent the growth and metabolism of bacteria, is urgently needed. In this work, a benzophenone\u2010derived phosphatase light\u2010triggered antibacterial agent is designed and synthesized, which is tethered to the biological materials using a one\u2010step method for in vivo antibacterial therapy. This surface could kill gram\u2010positive bacteria (<jats:italic>Staphylococcus aureus<\/jats:italic>) and gram\u2010negative bacteria (<jats:italic>Escherichia coli<\/jats:italic>). More importantly, because this material exhibited a zwitterion structure, it does not damage blood cells and tissue cells. When the bacteria interact with this surface, the initial fouling of the bacteria is reduced by zwitterion hydration. When the bacteria actively accumulate and metabolize to produce a certain amount of alkaline phosphatase, the surface immediately started the sterilization performance, and the bactericidal effect is achieved by destroying the bacterial cell membrane. In summary, an antibacterial biomaterial that shows biocompatibility with mammalian cells is successfully constructed, providing new ideas for the development of intelligent urinary catheters.<\/jats:p>","DOI":"10.1002\/adhm.202202421","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T07:04:26Z","timestamp":1671692666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Construction of Alkaline Phosphatase\u2010Responsive Biomaterial and Its Application for In Vivo Urinary Tract Infection Therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Jilin Medical University  Jilin 132013 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fu","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtao","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory of Medical Implantable Devices Key Laboratory for Medical Implantable Devices of Shandong Province WEGO Holding Company Limited  Weihai 264210 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moli","family":"Yin","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhe","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjie","family":"Yan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory of Medical Implantable Devices Key Laboratory for Medical Implantable Devices of Shandong Province WEGO Holding Company Limited  Weihai 264210 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-8440","authenticated-orcid":false,"given":"Huiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 P. R. 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