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Herein, a dynamic membrane\u2010active glycopeptide is developed by grafting with 25% maltotriose and 50%\n                    <jats:italic>p<\/jats:italic>\n                    \u2010benzyl alcohol for the first time to effectively facilitate entry of membrane\u2010impermeable trehalose in human RBCs with low hemolysis. Results of the mechanism acting on cell membranes suggest that reversible adsorption of such benzyl alcohol\u2010grafted glycopeptide on cell surfaces upon weak perturbation with phospholipids and dynamic transition toward membrane stabilization are essential for keeping cellular biofunctions. Furthermore, the functionalized glycopeptide is indicative of typical\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010helical\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sheet structure\u2010driven regulations of ice crystals during freeze\u2212thaw, thereby strongly promoting efficient cryopreservation. Such all\u2010in\u2010one glycopeptide enables achieving both high cell recovery post\u2010thaw &gt;85% and exceptional cryosurvival &gt;95% in direct freezing protocols. The rationally designed benzyl alcohol\u2010modified glycopeptide permits the development of a competent platform with high generality for protection of blood cells against freeze\u2010stress.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202202516","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T12:30:27Z","timestamp":1671712227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A Dynamic Membrane\u2010Active Glycopeptide for Enhanced Protection of Human Red Blood Cells against Freeze\u2010Stress"],"prefix":"10.1002","volume":"12","author":[{"given":"Shuhui","family":"Gao","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University  Tianjin 300350 P. R. 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