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However, current clinical therapeutic technologies still have many problems in targeting, enrichment, penetration, and safety to meet the thrombosis treatment needs. Therefore, researchers devote themselves to developing nanosystems loaded with antithrombotic drugs to address this paradox in recent years. Herein, the existing thrombosis treatment technologies are first reviewed; and then, their advantages and disadvantages are outlined based on a brief discussion of thrombosis's definition and formation mechanism. Furthermore, the need and application cases for introducing nanotechnology are discussed, focusing on thrombus\u2010specific targeted ligand modification technology and microenvironment\u2010triggered responsive drug release technology. Then, nanomaterials that can be used to design antithrombotic nanotherapeutic systems are summarized. Moreover, a variety of drug delivery technologies driven by nanomotors in thrombosis therapy is also introduced. Last of all, a prospective discussion on the future development of nanotechnology for thrombosis therapy is highlighted.<\/jats:p>","DOI":"10.1002\/adhm.202202578","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T10:03:44Z","timestamp":1670839424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Application of Nanotechnology in Thrombus Therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Shuyin","family":"Zhou","sequence":"first","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"},{"name":"Department of Vascular Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 210008 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