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Current techniques based on metallic coils, flow diverters, liquid embolics, and suspended microspheres are limited in their ability to address a wide variety of vasculature and can be plagued by complications including distal migration, compaction, and inappropriate vascular remodeling. Further, these endovascular devices currently offer limited therapeutic functions beyond flow control such as drug delivery. Herein, a novel in situ microcatheter\u2010based photomodulated extrusion approach capable of dynamically tuning the physical and morphological properties of injectable hydrogels, optimizing for local hemodynamic environment and vascular morphology, is proposed and demonstrated. A shear thinning and photoactivated poly(ethylene glycol diacrylate)\u2010nanosilicate (PEGDA\u2010nSi) hydrogel is used to demonstrate multiple extrusion modes which are controlled by photokinetics and device configurations. Real\u2010time photomodulation of injected hydrogel viscosity and modulus is successfully used for embolization in various vasculatures, including high\u2010flow large vessels and arterial\u2010to\u2010arterial capillary shunts. Furthermore, a generalizable therapeutic delivery platform is proposed by demonstrating a core\u2013shell structured extrusion encapsulating doxorubicin to achieve a more sustained release compared to unencapsulated payload.<\/jats:p>","DOI":"10.1002\/adhm.202202632","type":"journal-article","created":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T04:04:00Z","timestamp":1674360240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Photomodulated Extrusion as a Localized Endovascular Hydrogel Deposition Method"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-2197","authenticated-orcid":false,"given":"Yuta","family":"Dobashi","sequence":"first","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario M5S 1A1 Canada"},{"name":"Sunnybrook Research Institute  Toronto Ontario M4N 3M5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-8572","authenticated-orcid":false,"given":"Jerry C.","family":"Ku","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario M5S 1A1 Canada"},{"name":"Sunnybrook Research Institute  Toronto Ontario M4N 3M5 Canada"},{"name":"Division of Neurosurgery Department of Surgery University of Toronto  Toronto Ontario M5S 1A1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-4091","authenticated-orcid":false,"given":"Joel","family":"Ramjist","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto Ontario M4N 3M5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-7111","authenticated-orcid":false,"given":"Christopher","family":"Pasarikovski","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario M5S 1A1 Canada"},{"name":"Sunnybrook Research Institute  Toronto Ontario M4N 3M5 Canada"},{"name":"Division of Neurosurgery Department of Surgery University of Toronto  Toronto Ontario M5S 1A1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-6858","authenticated-orcid":false,"given":"Konrad","family":"Walus","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering School of Biomedical Engineering University of British Columbia  Vancouver British Columbia V6T 1Z4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-4712","authenticated-orcid":false,"given":"John D. 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