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As conventional ischemic stroke models fail to predict therapeutic efficacy, in vitro neurovascular unit (NVU)\/blood\u2013brain barrier (BBB) models are utilized to model ischemic stroke through replicating the cell\u2013cell interactions and mimicking the blood flow and anatomical features of the brain. Here, an overview of transwell, microfluidic, and hydrogel\u2010based NVU\/BBB models is provided, including cell types, engineering approaches, and the simulation of physiological and pathological features of NVU\/BBB after ischemic stroke. 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