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In this study, an injectable, conductive hydrogel is developed exhibiting remarkable mechanical strength that can withstand a pressure of 500 kPa (85% deformation rate) and display good fatigue resistance, electrical conductivity, and tissue adhesion. A stable covalent cross\u2010linked network with a slip\u2010ring structure by threading amino <jats:italic>\u03b2<\/jats:italic>\u2010cyclodextrin is formed onto the chain of a four\u2010armed (polyethylene glycol) amino group, and then reacted with the four\u2010armed (polyethylene glycol) maleimide under physiological conditions. The addition of silver nanowires enhances the hydrogel's electrical conductivity, enabling it to act as a good conductor in vivo. The hydrogel is injected into the fascial space, and the results show that the weight and muscle tone of the atrophied gastrocnemius muscle improve, subsequently alleviating muscle atrophy. Overall, this study provides a simple method for the preparation of a conductive hydrogel with high mechanical properties. In addition, the interstitial injection provides a strategy for the use of hydrogels in vivo.<\/jats:p>","DOI":"10.1002\/adhm.202202707","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T04:34:55Z","timestamp":1688618095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interstitial Injection of Hydrogels with High\u2010Mechanical Conductivity Relieves Muscle Atrophy Induced by Nerve Injury"],"prefix":"10.1002","volume":"12","author":[{"given":"Kai","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Science Beijing University of Chinese Medicine  Beijing 100029 China"},{"name":"CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhu","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in 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