{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:58:45Z","timestamp":1791608325267,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371987"],"award-info":[{"award-number":["81371987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Polyether ether ketone (PEEK) has become one of the most promising polymer implants in bone orthopedics, due to the biocompatibility, good processability, and radiation resistance. However, the poor mechanics\u2010adaptability\/osteointegration\/osteogenesis\/antiinfection limits the long\u2010term in vivo applications of PEEK implants. Herein, a multifunctional PEEK implant (PEEK\u2010PDA\u2010BGNs) is constructed through in situ surface deposition of polydopamine\u2010bioactive glass nanoparticles (PDA\u2010BGNs). PEEK\u2010PDA\u2010BGNs exhibit good performance on osteointegration and osteogenesis in vitro and in vivo, due to their multifunctional properties including mechanics\u2010adaptability, biominerialization, immunoregulation, anti\u2010infection, and osteoinductive activity. PEEK\u2010PDA\u2010BGNs can show the bone tissue\u2010adaptable mechanic surface and induce the rapid biomineralization (apatite formation) under a simulated body solution. Additionally, PEEK\u2010PDA\u2010BGNs can induce the M2 phenotype polarization of macrophages, reduce the expression of inflammatory factors, promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and improve the osseointegration and osteogenesis ability of the PEEK implant. PEEK\u2010PDA\u2010BGNs also show good photothermal antibacterial activity and can kill 99% of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ) and Methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), suggesting their potential antiinfection ability. This work suggests that PDA\u2010BGNs coating is probably\u00a0a facile strategy to construct multifunctional (biomineralization, antibacterial, immunoregulation) implants for bone tissue replacement.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202202799","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T17:04:26Z","timestamp":1676653466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Engineering Multifunctional Polyether Ether Ketone Implant: Mechanics\u2010Adaptability, Biominerialization, Immunoregulation, Anti\u2010Infection, Osteointegration, and Osteogenesis"],"prefix":"10.1002","volume":"12","author":[{"given":"Hongyun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Frontier Institute of Science and Technology Xi'an Jiaotong University  Xi'an 710000 P. R. China"},{"name":"Department of Orthopedics Qinghai Provincial People's Hospital  Qinghai 810007 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Frontier Institute of Science and Technology Xi'an Jiaotong University  Xi'an 710000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Frontier Institute of Science and Technology Xi'an Jiaotong University  Xi'an 710000 P. R. 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