{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:03:49Z","timestamp":1790107429601,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to investigate the bone regeneration effect of bovine hydroxyapatite\u2010processed biomaterials Bone\u2010XB and S1\u2010XB in a beagle mandibular defect model. A total of four saddle\u2010type critical sizes (15\u00a0mm\u00a0\u00d7\u00a010\u00a0mm) bone defects are created in each dog: two defects in the left mandible and two defects in the right mandible. The defect control (DC) group is kept unfilled, and the other three defects are filled with three different biomaterials as follows: positive control Bio\u2010Oss (Bio\u2010Oss group), Bone\u2010XB (XB group), and S1\u2010XB (S1\u2010XB group). Bone regeneration is evaluated by radiography, micro\u2010computed tomography, and histological analysis. It is revealed that Bone\u2010XB and S1\u2010XB significantly increase newly formed bone, defect filling percentage, and bone healing score compared to the DC group, which is confirmed by bone microstructure augmentation (bone volume\/total volume, trabecular number, and trabecular thickness). Interestingly, no significant differences are observed between the Bone\u2010XB, S1\u2010XB, and Bio\u2010Oss groups. It is suggested that Bone\u2010XB or S1\u2010XB stimulates bone regeneration demonstrated by the increase in newly formed bone and bone microstructure, thereby improving bone defect filling, which is equivalent to the Bio\u2010Oss. Therefore, bovine hydroxyapatite\u2010processed Bone\u2010XB or S1\u2010XB can be considered effective biomaterials for correcting critical\u2010size bone defects or fractures.<\/jats:p>","DOI":"10.1002\/adhm.202202942","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T11:39:05Z","timestamp":1685533145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Investigation of Bone Regeneration Efficacy of New Bovine Bone Minerals in a Canine Mandibular Critical Defect Model"],"prefix":"10.1002","volume":"12","author":[{"given":"Sung\u2010Jin","family":"Park","sequence":"first","affiliation":[{"name":"Research Center HLB bioStep Co., Ltd.  Incheon 22014 Republic of Korea"},{"name":"Laboratory of Hygienic Pharmacy College of Pharmacy Chungbuk National University  Cheongju 28160 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mahbubur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Research Center HLB bioStep Co., Ltd.  Incheon 22014 Republic of Korea"},{"name":"Department of Physiology College of Medicine Gachon University  Incheon 21936 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaebum","family":"Lee","sequence":"additional","affiliation":[{"name":"Medpark Co., Ltd.  Seoul 07282 Republic of Korea"},{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Research Adams School of Dentistry University of North Carolina  Chapel Hill NC 27599 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk\u2010Woong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic surgery Busan National University Yangsan Hospital  Yangsan 50612 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-433X","authenticated-orcid":false,"given":"Sokho","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Center HLB bioStep Co., Ltd.  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