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Metal\u2010phenolic networks (MPNs) have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and antimicrobial properties brought about by polyphenols and metal ions. However, typical therapeutic MPNs show rapid release of metal ions due to their poor solution stability, impeding long\u2010acting efficacy in multiple wound healing stages. To address these issues, copper\u2010poly (tannic acid) nanoparticles (Cu\u2010PTA NPs): robust (dually crosslinked), microenvironment\u2010responsive, antibacterial, antioxidative, and anti\u2010inflammatory are prepared, which hierarchically modulate the infected wound healing process. Covalently polymerized via phenol\u2010formaldehyde condensation and crosslinked with bioactive Cu<jats:sup>2+<\/jats:sup>, reactive polyphenols are preserved, and Cu<jats:sup>2+<\/jats:sup> is efficiently entrapped in the PTA scaffold. The proposed strategy relieves the systemic toxicity, and only high reactive oxygen species (ROS)level as stimuli can \u201cturn on\u201d the catalytic activity of Cu<jats:sup>2+<\/jats:sup> to implement antibacterial therapy specifically in an infected wound. Systematic tissue regeneration assessment on the infected full\u2010thickness skin wounds of rats demonstrates enhanced wound healing rate. Cu\u2010PTA NPs enables the direct application in infected wound and exertion of long\u2010acting healing efficacy. This synergetic therapy strategy will pave the way for more complicated infections and inflammatory diseases.<\/jats:p>","DOI":"10.1002\/adhm.202203063","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T09:49:00Z","timestamp":1677404940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Dually Crosslinked Copper\u2010Poly(tannic acid) Nanoparticles with Microenvironment\u2010Responsiveness for Infected Wound Treatment"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-428X","authenticated-orcid":false,"given":"Dongying","family":"Li","sequence":"first","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong 510055 P. R. 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