{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:32:19Z","timestamp":1789525939917,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003662","name":"Korea Evaluation Institute of Industrial Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Regenerative wound healing involves the scarless wound healing as observed in fetal skin. Multiple features of regenerative wound healing have been well studied; however, the practical application of pro\u2010regenerative materials to recapitulate the regenerative wound healing in adult skins has not yet been achieved. In this study, the authors identified that their novel pro\u2010regenerative material, pyrogallol\u2010functionalized hyaluronic acid (HA\u2010PG) patches in combination with protein transduction domain\u2010fused Dishevelled (Dvl)\u2010binding motif (PTD\u2010DBM), a peptide inhibiting the CXXC\u2010type zinc finger protein 5 (CXXC5)\u2010Dvl interaction, promoted regenerative wound healing in mice. The HA\u2010PG patches loaded with this competitor peptide and valproic acid (VPA), a glycogen synthase kinase 3\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (GSK3\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) inhibitor, significantly inhibited scar formation during wound healing. The HA\u2010PG patches with PTD\u2010DBM and\/or VPA inhibit the expression of differentiated cell markers such as\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010smooth muscle actin (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010SMA) while inducing the expression of stem cell markers such as CD105 and Nestin. Moreover, Collagen III, an important factor for regenerative healing, is critically induced by the HA\u2010PG patches with PTD\u2010DBM and\/or VPA, as also seen in VPA\u2010treated\n                    <jats:italic>Cxxc5<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse fibroblasts. Overall, these findings suggest that the novel regeneration\u2010promoting material can be utilized as a potential therapeutic agent to promote both wound healing and scar attenuation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202203094","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T18:33:10Z","timestamp":1677609190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Adhesive Hydrogel Patch\u2010Mediated Combination Drug Therapy Induces Regenerative Wound Healing through Reconstruction of Regenerative Microenvironment"],"prefix":"10.1002","volume":"12","author":[{"given":"Soung\u2010Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of Korea"},{"name":"CK Regeon Inc.  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