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Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory cytokine release, and extracellular matrix (ECM) synthesis. Thus, it is reasoned that reducing excess reactive oxygen species (ROS) in the chondrocyte microenvironment may be an effective therapeutic strategy for TMJ OA. Recently, cascade nanozymes, including Pt@PCN222\u2010Mn, have been exploited to treat ROS\u2010associated diseases. Nevertheless, cascade nanozymes are not employed for TMJ OA therapy. To fill this gap, it is explored whether the Pt@PCN222\u2010Mn cascade nanozyme could be applied to the treatment of TMJ OA. The in vitro results demonstrate that the Pt@PCN222\u2010Mn nanozyme can inhibit the production of inflammatory factors, the degradation of ECM, and the apoptosis of chondrocytes by inhibiting the ROS\u2010nuclear factor kappa\u2010B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B_ and mitogen\u2010activated protein kinase signaling pathways. The in vivo results further demonstrate that the Pt@PCN222\u2010Mn nanozyme can delay the progression of TMJ OA in the rat unilateral anterior crossbite model. It is believed that insightful perspectives on the application of nanozymes in TMJ OA will be provided here.<\/jats:p>","DOI":"10.1002\/adhm.202203195","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T05:05:09Z","timestamp":1675487109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS\u2010NF\u2010<i>\u03ba<\/i>B and MAPK Pathways"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhongyin","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  140 Hanzhong Road Nanjing Jiangsu 210029 China"},{"name":"Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical University  136 Hanzhong Road Nanjing Jiangsu 210029 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