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However, the introduction of QAS commonly leads to high cytotoxicity and adhesive deterioration. Herein, aimed to solve these two issues, a self\u2010adaptive dressing with delicate spatiotemporal responsiveness is developed by employing cellulose sulfate (CS) as dynamic layers to coat QAS\u2010based hydrogel. In detail, due to the acid environment of wound in the early stages of healing, the CS coating will quickly detach to expose the active QAS groups for maximum disinfectant efficacy; meanwhile, as the wound gradually heals and recovers to a neutral pH, the CS will remain stable to keep QAS screened, realizing a high cell growth\u2010promoting activity for epithelium regeneration. Additionally, attributed to the synergy of temporary hydrophobicity by CS and slow water absorption kinetics of the hydrogel, the resultant dressing possesses outstanding wound sealing and hemostasis performance. At last, this work anticipates this approach to intelligent wound dressings based on dynamic and responsive intermolecular interaction can also be applied to a wide range of self\u2010adaptive biomedical materials employing different chemistries for applications in medical therapy and health monitoring.<\/jats:p>","DOI":"10.1002\/adhm.202203241","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:44:36Z","timestamp":1684925076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Spatiotemporally Responsive Hydrogel Dressing with Self\u2010Adaptive Antibacterial Activity and Cell Compatibility for Wound Sealing and Healing"],"prefix":"10.1002","volume":"12","author":[{"given":"Wei","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Nanjing University of Science and Technology  Nanjing 210094 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