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Meanwhile, when used alone, the traditional first\u2010line chemotherapeutic agent gemcitabine (GEM) in PDAC treatment is also insufficient to achieve lasting efficacy. In this study, a reactive oxygen species degradable hydrogel system, denoted as GEM\u2010STING@Gel, is engineered to codeliver gemcitabine and the stimulator of interferon genes (STING) agonist DMXAA (5,6\u2010dimethylxanthenone\u20104\u2010acetic acid) into the tumor site. In this work, the strategy addresses the major challenges of current immunotherapies with a facile platform, which can synergistically activate innate immunity and promote the cytotoxic T lymphocytes infiltration at the tumor site, thereby modulating the immunosuppressive TME. Further, the efficient therapeutic potency of the immunotherapy is confirmed in an orthotopic postsurgical model, unleashing the translational potential to prevent tumor recurrence after surgical resection. This study underscores the advantages of this integrative strategy that combines chemotherapy, immunotherapy, and biomaterial\u2010based hydrogel, including improved therapeutic efficacy, operational convenience, and superior biosafety.<\/jats:p>","DOI":"10.1002\/adhm.202203264","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T05:17:54Z","timestamp":1679894274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["In Situ Formed ROS\u2010Responsive Hydrogel with STING Agonist and Gemcitabine to Intensify Immunotherapy against Pancreatic Ductal Adenocarcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Meng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 310003 China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease  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