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Previous studies confirmed that zinc oxide (ZnO) NPs can enter the brain through the tongue\u2212brain pathway, but it is unclear whether they will further affect synaptic transmission and brain perception. In this study, it is found that tongue\u2212brain\u2010transported ZnO NPs can cause a decrease in taste sensitivity and taste aversion learning ability, indicating abnormal taste perception. Moreover, the release of miniature excitatory postsynaptic currents, the frequency of action potential release, and the expression of c\u2010fos are decreased, suggesting that the synaptic transmission is reduced. To further explore the mechanism, protein chip detection of inflammatory factors is carried out and it is found that neuroinflammation occurs. Importantly, it is found that neuroinflammation originated from neurons. The JAK\u2010STAT signaling pathway is activated, which inhibits the Neurexin1\u2010PSD95\u2010Neurologigin1 pathway and c\u2010fos expression. Blocking the activation of the JAK\u2010STAT pathway prevents neuroinflammation and the reduction in Neurexin1\u2010PSD95\u2010Neurologigin1. These results indicate that ZnO NPs can be transported by the tongue\u2212brain pathway and lead to abnormal taste perception by neuroinflammation\u2010induced deficits in synaptic transmission. The study reveals the influence of ZnO NPs on neuronal function and provides a novel mechanism.<\/jats:p>","DOI":"10.1002\/adhm.202203316","type":"journal-article","created":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T18:39:40Z","timestamp":1678646380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tongue\u2212Brain\u2010Transported ZnO Nanoparticles Induce Abnormal Taste Perception"],"prefix":"10.1002","volume":"12","author":[{"given":"Aijie","family":"Chen","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital Peking University  Shenzhen 518000 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