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However, conjugation capacity in standard coupling reactions, such as carbodiimide chemistry, is limited by low yield and lack of abundant conjugation sites. Here, a simple oxidative polymerization step before conjugation of catechol\u2010carrying molecules (i.e., 3,4\u2010dihydroxy\u2010<jats:sc>l<\/jats:sc>\u2010phenylalanine, <jats:sc>l<\/jats:sc>\u2010DOPA) as a potential approach to amplify catechol function in bioadhesion of natural gelatin biomaterials is proposed. Solutions of gelatin modified with poly(<jats:sc>l<\/jats:sc>\u2010DOPA) moieties (GelDOPA) are characterized by faster physical gelation and increased viscosity, providing better wound control on double\u2010curved tissue surfaces compared to those of <jats:sc>l<\/jats:sc>\u2010DOPA\u2010conjugated gelatin. Physical hydrogels treated topically with low concentrations of NaIO<jats:sub>4<\/jats:sub> solutions are crosslinked on\u2010demand via through\u2010thickness diffusion. Poly(<jats:sc>l<\/jats:sc>\u2010DOPA) conjugates enhance crosslinking density compared to <jats:sc>l<\/jats:sc>\u2010DOPA conjugated gelatin, resulting in lower swelling and enhanced cohesion in physiological conditions. Together with cohesion, more robust bioadhesion at body temperature is achieved by poly(<jats:sc>l<\/jats:sc>\u2010DOPA) conjugates, exceeding those of commercial sealants. Further, poly(<jats:sc>l<\/jats:sc>\u2010DOPA) motifs introduced photothermal responsiveness via near\u2010infrared (NIR) irradiation for controlled drug release and potential applications in photothermal therapy. The above functionalities, along with antibacterial activity, render the proposed approach an effective biomaterial design strategy for wound closure applications.<\/jats:p>","DOI":"10.1002\/adhm.202203404","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T23:55:01Z","timestamp":1677455701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Poly\u2010Catecholic Functionalization of Biomolecules for Rapid Gelation, Robust Injectable Bioadhesion, and Near\u2010Infrared Responsiveness"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-2667","authenticated-orcid":false,"given":"Hossein","family":"Montazerian","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of California, Los Angeles  Los Angeles CA 90095 USA"},{"name":"California NanoSystems Institute University of California, Los Angeles  Los Angeles CA 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