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Herein, a new near\u2010infrared (NIR) fluorescence nanoprobe is designed and synthesized with aggregation\u2010induced emission (AIE) features, which also is excellent reactive oxygen species (ROS) generator. The as\u2010prepared AIE nanoparticles (NPs) present outstanding sterilizing rate on methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) and kanamycin\u2010resistant <jats:italic>Escherichia coli<\/jats:italic> (KREC). Meanwhile, considering the differences in the surface structure of animal cells and bacteria, a non\u2010invasive image\u2010guided strategy for precise treatment of bacterial infection has been successfully implemented based on bioorthogonal reaction which can perform and control unnatural chemical reactions inside living organisms. The AIE NPs are thus specifically trapped on the bacterial surface while not on the normal cells, realizing real\u2010time tracking of the infected site distribution in vivo and guiding photodynamic therapy (PDT) for eliminating bacteria in inflammation region. That significantly improves the accuracy and sterilization rate of bacterial\u2010infected wounds with negligible side effects. The investigation developed a potential antibacterial agent and also provides an instructive way for targeting treatment based on bioorthogonal reaction.<\/jats:p>","DOI":"10.1002\/adhm.202300044","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T13:33:07Z","timestamp":1687872787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["AIE Bioconjugates for Accurate Identification and In Vivo Targeted Treatment of Bacterial Infection Based on Bioorthogonal Reaction"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-8934","authenticated-orcid":false,"given":"Yuan","family":"Fang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin Key Laboratory of Food Quality and Health Tianjin University of Science and Technology  Tianjin 300457 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