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In this domain, polyethylene glycol (PEG) has become increasingly popular as a biomedical polymer and has found clinical use. Owing to their excellent biocompatibility, facile modifiability, and high drug encapsulation rate, PEG hydrogels have shown great promise as drug delivery platforms. Here, the progress in emerging novel designs of PEG\u2010hydrogels as DDSs for anti\u2010cancer therapy is reviewed and discussed, focusing on underpinning multiscale release mechanisms categorized under stimuli\u2010responsive and non\u2010responsive drug release. The responsive drug delivery approaches are discussed, and the underpinning release mechanisms are elucidated, covering the systems functioning based on either exogenous stimuli\u2010response, such as photo\u2010 and magnetic\u2010sensitive PEG hydrogels, or endogenous stimuli\u2010response, such as enzyme\u2010, pH\u2010, reduction\u2010, and temperature\u2010sensitive PEG hydrogels. Special attention is paid to the commercial potential of PEG\u2010based hydrogels in cancer therapy, highlighting the limitations that need to be addressed in future research for their clinical translation.<\/jats:p>","DOI":"10.1002\/adhm.202300105","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T07:29:43Z","timestamp":1681370983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["Poly Ethylene Glycol (PEG)\u2010Based Hydrogels for Drug Delivery in Cancer Therapy: A Comprehensive Review"],"prefix":"10.1002","volume":"12","author":[{"given":"Zihan","family":"Wang","sequence":"first","affiliation":[{"name":"College of Chemistry Nankai University  Tianjin 300071 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinzhou","family":"Ye","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University  Sichuan 611130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province China West Normal University  Nanchong 637000 P. R. 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