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Herein, a series of organic photosensitizers (PSs) with donor\u2010acceptors (D\u2010A) are elaborately designed and synthesized. In particular, PPR\u20102CN exhibits stable near infrared\u2010I (NIR\u2010I) emission, excellent free radicals generation and phototoxicity. Experimental analysis and calculations imply that a small singlet\u2010triplet energy gap (\u0394\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>S1\u2212T1<\/jats:sub>\n                    ) and large spin\u2010orbit coupling (SOC) constant boost the intersystem crossing (ISC), leading to type\u2010I photodynamic therapy (PDT). Additionally, the specific glutamate (Glu) and glutathione (GSH) consumption abilities of PPR\u20102CN inhibit the intracellular biosynthesis of GSH, resulting in redox dyshomeostasis and GSH\u2010depletion causing ferroptosis. This work first realizes that single component organic PS could be simultaneously used as a type\u2010I photodynamic agent and metal\u2010free ferroptosis inducer for NIR\u2010I imaging\u2010guided multimodal synergistic therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300134","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T05:14:00Z","timestamp":1681794840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Single Component Organic Photosensitizer with NIR\u2010I Emission Realizing Type\u2010I Photodynamic and GSH\u2010Depletion Caused Ferroptosis Synergistic Theranostics"],"prefix":"10.1002","volume":"12","author":[{"given":"Laiping","family":"Fang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials College of Chemistry Jilin University  Qianjin Street 2699 Changchun 130012 P. 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