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Although some studies have attempted to use hydrogels to repair corneal damage, most of these hydrogels can only be used for focal stromal defects that are \u22643.5\u00a0mm in diameter due to poor hydrogel adhesion. Here, a photocurable adhesive hydrogel that mimics the extracellular matrix (ECM) with regard to composition for repairing 6\u00a0mm\u2010diameter corneal stromal defects in rabbits is investigated. This ECM\u2010like adhesive can be rapidly cured after light exposure, with high light transmittance and good mechanical properties. More importantly, this hydrogel maintains the viability and adhesion of cornea\u2010derived cells and promotes their migration in vitro in 2D and 3D culture environments. Proteomics analysis confirms that the hydrogel promotes cell proliferation and ECM synthesis. Furthermore, in rabbit corneal stromal defect repair experiments, it is proven by histological and proteomic analysis that this hydrogel can effectively promote corneal stroma repair, reduce scar formation, and increase corneal stromal\u2013neural regeneration at the six\u00a0months follow\u2010up. This work demonstrates the great application of ECM\u2010like adhesive hydrogels for the regeneration of large\u2010diameter corneal defects.<\/jats:p>","DOI":"10.1002\/adhm.202300192","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T12:43:20Z","timestamp":1682426600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["ECM\u2010Like Adhesive Hydrogel for the Regeneration of Large Corneal Stromal Defects"],"prefix":"10.1002","volume":"12","author":[{"given":"Fuyan","family":"Wang","sequence":"first","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology School of Ophthalmology, Shandong First Medical University  Qingdao 266071 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