{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:06:05Z","timestamp":1790183165192,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102113"],"award-info":[{"award-number":["82102113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M691242"],"award-info":[{"award-number":["2021M691242"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Currently, undeveloped diagnosis and delayed treatment of bacteria\u2010infected sites in vivo not only expand the risk of tissue infection but are also a major clinical cause of multiple drug\u2010resistant bacterial infections. Herein, an efficient nanoplatform for near\u2010infrared (NIR)\u2010light\u2010controlled release and bacteria\u2010targeted delivery of nitric oxide (NO) combined with photothermal therapy (PTT) is presented. Using maltotriose\u2010decorated mesoporous polydopamine (MPDA\u2010Mal) and BNN6, a smart antibacterial (B@MPDA\u2010Mal) is developed to combine bacterial targeting, gas\u2010controlled release, and PTT. Utilizing bacteria's unique maltodextrin transport system, B@MPDA\u2010Mal can accurately distinguish bacterial infection from sterile inflammation and target the bacteria\u2010infected sites for efficient drug enrichment. Moreover, NIR\u2010light causes MPDA to generate heat, which not only effectively induces BNN6 to produce NO, but also raises the temperature to harm the bacteria further. NO\/photothermal combination therapy effectively eliminates biofilm and drug\u2010resistant bacteria. The myositis model of methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> infection is established and indicates that B@MPDA\u2010Mal can successfully eradicate inflammation and abscesses in mice. Meanwhile, magnetic resonance imaging technology is used to monitor the treatment procedure and healing outcomes. Given the aforementioned advantages, the smart antibacterial nanoplatform B@MPDA\u2010Mal can be used as a potential therapeutic tool in the biomedical field against drug\u2010resistant bacterial infections.<\/jats:p>","DOI":"10.1002\/adhm.202300247","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T14:24:46Z","timestamp":1680359086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Bacteria\u2010Targeted Combined with Photothermal\/NO Nanoparticles for the Treatment and Diagnosis of MRSA Infection In Vivo"],"prefix":"10.1002","volume":"12","author":[{"given":"Kai","family":"Lv","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University  Guangzhou 510632 China"},{"name":"MOE Key Laboratory of Tumor Molecular Biology Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\/CT\u2010MRI Center The First Affiliated Hospital of Jinan University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Guangdong Provincial People's Hospital Southern Medical University  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University  Guangzhou 510632 China"},{"name":"MOE Key Laboratory of Tumor Molecular Biology Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Zhucheng People's Hospital  Zhucheng 262200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\/CT\u2010MRI Center The First Affiliated Hospital of Jinan University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-7348","authenticated-orcid":false,"given":"Dong","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University  Guangzhou 510632 China"},{"name":"MOE Key Laboratory of Tumor Molecular Biology Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112318"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM90100H"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035415"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01246"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.5.2.193"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.07.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121084"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.05.006"},{"key":"e_1_2_9_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.131216"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-018-7537-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201905697"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM01077H"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2021.08.003"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202100227"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn700191f"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110556"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07484E"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR06630A"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR00231A"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc40491a"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804046"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101447"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802290"},{"key":"e_1_2_9_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801047"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08667"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2018.04.159"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201707440"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115928"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR04540C"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2018.10.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.24.8322-8331.2005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700543"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14985-8"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202103627"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408533"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3074"},{"key":"e_1_2_9_29_1","first-page":"2427","volume":"13","author":"Pang X.","year":"2019","journal-title":"ACS Nano"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.02.029"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12081348"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.12.011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-021-1045-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR01859K"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119304"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.07.012"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202004698"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR04748K"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206959"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.06.011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.006"}],"updated-by":[{"DOI":"10.1002\/adhm.202503709","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000}}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202300247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:37:44Z","timestamp":1759750664000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202300247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":52,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/adhm.202300247"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202300247","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]},"assertion":[{"value":"2023-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300247"}}