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Prior to irradiation by a BT device, their delivery to tumors can enhance the radiation effect by generating low\u2010energy photons and electrons, leading to reactive oxygen species (ROS) production, lethal to cells. No efficient delivery system has been proposed until now for AuNP topical delivery to localized cervical cancer in the context of BT. This article reports an original approach developed to accelerate the preclinical studies of AuNP\u2010enhanced BT procedures. First, an AuNP\u2010containing hydrogel (Pluronic F127, alginate) is developed and tested in mice for degradation, AuNP release, and biocompatibility. Then, custom\u2010made 3D\u2010printed radioactive BT inserts covered with a AuNP\u2010containing hydrogel cushion are designed and administered by surgery in mice (HeLa xenografts), which allows for measuring AuNP penetration in tumors (\u2248100\u00a0\u00b5m), co\u2010registered with the presence of ROS produced through the interactions of radiation and AuNPs. Biocompatible AuNPs\u2010releasing hydrogels could be used\u00a0in the treatment of cervical cancer prior to BT, with impact on\u00a0 the total amount of radiation needed per BT treatment, which will result in benefits to the preservation of healthy tissues surrounding cancer.<\/jats:p>","DOI":"10.1002\/adhm.202300305","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:29:14Z","timestamp":1682357354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gold\u2010Enhanced Brachytherapy by a Nanoparticle\u2010Releasing Hydrogel and 3D\u2010Printed Subcutaneous Radioactive Implant Approach"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-8175","authenticated-orcid":false,"given":"Mariia","family":"Kiseleva","sequence":"first","affiliation":[{"name":"D\u00e9partement de G\u00e9nie des Mines de la M\u00e9tallurgie et des Mat\u00e9riaux Centre de Recherche sur les Mat\u00e9riaux Avanc\u00e9s (CERMA) Universit\u00e9 Laval  Qu\u00e9bec G1V 0A6 Canada"},{"name":"Laboratoire de Biomat\u00e9riaux pour l'Imagerie M\u00e9dicale Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval  Qu\u00e9bec G1V 4G2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9ophraste","family":"Lescot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9nie des Mines de la M\u00e9tallurgie et des Mat\u00e9riaux Centre de Recherche sur les Mat\u00e9riaux Avanc\u00e9s (CERMA) Universit\u00e9 Laval  Qu\u00e9bec G1V 0A6 Canada"},{"name":"Laboratoire de Biomat\u00e9riaux pour l'Imagerie M\u00e9dicale Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval  Qu\u00e9bec G1V 4G2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Selivanova","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 Laval  Qu\u00e9bec G1V 0A6 Canada"},{"name":"Axe Oncologie Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval  Qu\u00e9bec G1R 3S3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-466X","authenticated-orcid":false,"given":"Marc\u2010Andr\u00e9","family":"Fortin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9nie des Mines de la M\u00e9tallurgie et des Mat\u00e9riaux Centre de Recherche sur les Mat\u00e9riaux Avanc\u00e9s (CERMA) Universit\u00e9 Laval  Qu\u00e9bec G1V 0A6 Canada"},{"name":"Laboratoire de Biomat\u00e9riaux pour l'Imagerie M\u00e9dicale Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval  Qu\u00e9bec G1V 4G2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00501-0"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.11.052"},{"key":"e_1_2_9_3_1","volume-title":"The Bethesda Handbook of Clinical Oncology","author":"Abraham J.","year":"2022"},{"key":"e_1_2_9_4_1","first-page":"8","volume":"11","author":"Chao X. 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