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Splenic operations such as splenectomy and intrasplenic injection are of paramount importance for immunological research and splenic diseases. Fluorescence imaging can vastly simplify these operations, but a specific spleen\u2010targeting probe is still unavailable. Herein, the first specific spleen\u2010accumulated fluorescent probe, VIX\u2010S is reported, which fluoresces at 1064\u00a0nm and is highly stable. Systematic studies reveal the superior targeting and imaging performance of VIX\u2010S for the spleen in both nude and haired mice. In vivo imaging indicates that the probe can image the morphology of spleen with a signal\u2010background ratio of at least two\u2010fold higher than that of the liver. Moreover, the application of VIX\u2010S in imaging\u2010guided splenic operation, including splenic injury and intrasplenic injection, is demonstrated, which may provide a practice tool for spleen research in the animal model.<\/jats:p>","DOI":"10.1002\/adhm.202300434","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T10:07:33Z","timestamp":1679998053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Specific Spleen\u2010Accumulated NIR\u2010II Fluorescent Probe for Imaging\u2010Guided Splenic Operation"],"prefix":"10.1002","volume":"12","author":[{"given":"Yiqing","family":"Yang","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"Key Laboratory of Chemical Biology of Hebei Province College of Chemistry and Environmental Science Hebei University  Baoding 071002 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diankai","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixu","family":"He","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-3997","authenticated-orcid":false,"given":"Wen","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200232060-00002"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1669"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00399-x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02115-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.14.2.8190956"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/tsaco-2017-000075"},{"key":"e_1_2_8_5_1","author":"Al\u2010Salem A. 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