{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:58:57Z","timestamp":1792159137704,"version":"4.4.0"},"reference-count":72,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vital pulp therapy (VPT) is considered a conservative treatment for preserving pulp viability in caries\u2010induced dental pulp infections. However, bacterial contamination negatively affects dentine\u2010pulp complex repair. The common capping materials show limited antimicrobial effects against some microorganisms. To improve the VPT efficacy, capping materials with increased antibacterial properties and enhanced odontogenic and angiogenic activities are needed. Herein, a SrCuSi\n                    <jats:sub>4<\/jats:sub>\n                    O\n                    <jats:sub>10<\/jats:sub>\n                    \/gelatin methacrylate(SC\/Gel) composite hydrogel has been proposed for infected dental pulp treatment. SrCuSi\n                    <jats:sub>4<\/jats:sub>\n                    O\n                    <jats:sub>10<\/jats:sub>\n                    (SC) is a microscale bioceramic composed of assembled multilayered nanosheets that possesses good near\u2010infrared photothermal conversion ability and multiple bioactivities due to sustained Sr\n                    <jats:sup>2+<\/jats:sup>\n                    , Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , and SiO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    ion release. It is shown that the SC\/Gel composite hydrogel efficiently eliminates\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus casei<\/jats:italic>\n                    and inhibits biofilm formation under photothermal heating, while the ion extract from SC promotes odontogenesis of rat dental pulp stem cells\u00a0and angiogenesis of human umbilical vein endothelial cells. The as\u2010designed therapeutic effect of SC\/Gel composite hydrogel\u2010mediated VPT has been proven in a rat dental pulp infection model and yielded improved dentine\u2010pulp complex repair compared with the commercially used iRoot\u00ae BP Plus. This study suggests that the SC\/Gel composite hydrogel is a potential pulp\u2010capping material with improved effects on dentine\u2212pulp complex repair in infected pulp.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300546","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T09:48:32Z","timestamp":1685612912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["SrCuSi\n                    <sub>4<\/sub>\n                    O\n                    <sub>10<\/sub>\n                    \/GelMA Composite Hydrogel\u2010Mediated Vital Pulp Therapy: Integrating Antibacterial Property and Enhanced Pulp Regeneration Activity"],"prefix":"10.1002","volume":"12","author":[{"given":"Yu","family":"Qiu","sequence":"first","affiliation":[{"name":"Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010Sen University Guangzhou Guangdong 510055 P. R. 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