{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:56:59Z","timestamp":1773982619412,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["834677"],"award-info":[{"award-number":["834677"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"Vinnova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The organic electronic ion pump (OEIP) is an on\u2010demand electrophoretic drug delivery device, that via electronic to ionic signal conversion enables drug delivery without additional pressure or volume changes. The fundamental component of OEIPs is their polyelectrolyte membranes which are shaped into ionic channels that conduct and deliver ionic drugs, with high spatiotemporal resolution. The patterning of these membranes is essential in OEIP devices and is typically achieved using laborious microprocessing techniques. Here, the development of an inkjet printable formulation of polyelectrolyte is reported, based on a custom anionically functionalized hyperbranched polyglycerol (i\u2010AHPG). This polyelectrolyte ink greatly simplifies the fabrication process and is used in the production of free\u2010standing OEIPs on flexible polyimide (PI) substrates. Both i\u2010AHPG and the OEIP devices are characterized, exhibiting favorable iontronic characteristics of charge selectivity and the ability to transport aromatic compounds. Further, the applicability of these technologies is demonstrated by the transport and delivery of the pharmaceutical compound bupivacaine to dorsal root ganglion cells with high spatial precision and effective nerve blocking, highlighting the applicability of these technologies for biomedical scenarios.<\/jats:p>","DOI":"10.1002\/adhm.202300550","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T23:34:55Z","timestamp":1681774495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Flexible Organic Electronic Ion Pump Fabricated Using Inkjet Printing and Microfabrication for Precision In Vitro Delivery of Bupivacaine"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-129X","authenticated-orcid":false,"given":"Dennis","family":"Cherian","sequence":"first","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-5366","authenticated-orcid":false,"given":"Arghyamalya","family":"Roy","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-1332","authenticated-orcid":false,"given":"Alex","family":"Bersellini Farinotti","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet  Stockholm 17177 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-1850","authenticated-orcid":false,"given":"Tobias","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7729-0251","authenticated-orcid":false,"given":"Theresia","family":"Arbring Sj\u00f6str\u00f6m","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-446X","authenticated-orcid":false,"given":"Klas","family":"Tybrandt","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-8463","authenticated-orcid":false,"given":"David","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Unit of Printed Electronics RISE Research Institutes of Sweden  Norrk\u00f6ping 60221 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5154-0291","authenticated-orcid":false,"given":"Magnus","family":"Berggren","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-4631","authenticated-orcid":false,"given":"Camilla I.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet  Stockholm 17177 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-8723","authenticated-orcid":false,"given":"David J.","family":"Poxson","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-3490","authenticated-orcid":false,"given":"Daniel T.","family":"Simon","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  Norrk\u00f6ping 60174 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000218"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87177-z"},{"key":"e_1_2_8_3_1","first-page":"1790","volume-title":"IEEE TRANSDUCERS 2009","author":"Simon D. T.","year":"2009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22680"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau1291"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202001302"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617758114"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2494"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/2058-8585\/ab17b1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.201800270"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202001006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc40093f"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4902909"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201700360"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TA07954G"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201500482"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma10060586"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604231113"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microrel.2015.05.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2017.2766700"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4908590"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac503029q"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.01.036"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35504-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2021.123664"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00484"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b05949"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4850795"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197811000-00004"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2004.12.003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200901141"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.201400432"},{"key":"e_1_2_8_33_1","volume-title":"Inkjet Technology for Digital Fabrication","author":"Hutchings I. M.","year":"2013"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200901141"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200300385"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(66)90082-8"},{"key":"e_1_2_8_37_1","unstructured":"Fujifilm Dimatix Materials Cartridge \u2013 Samba Cartridge https:\/\/asset.fujifilm.com\/www\/us\/files\/2021\u201004\/ae8a1e167ce8c273fcdd31ecffd9ec80\/PDS00142.pdf(accessed: April 2023)."},{"key":"e_1_2_8_38_1","unstructured":"Dataphysics Instruments Surface tension values of some common test liquids for surface energy analysis https:\/\/www.dataphysics\u2010instruments.com\/Downloads\/Surface\u2010Tensions\u2010Energies.pdf(accessed: April 2023)."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.43361"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.5370\/JEET.2012.7.1.91"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03886"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5b00429"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12193166"},{"key":"e_1_2_8_44_1","unstructured":"Ostemers Ostemer 220 Litho https:\/\/www.ostemers.com\/products\/ostemer\u2010litho\/(accessed: April 2023)."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1109\/JMEMS.2004.839328"},{"key":"e_1_2_8_46_1","first-page":"5","volume":"91","author":"Van\u00fdsek P.","year":"1996","journal-title":"Chem"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2006.03.012"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.461"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202300550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:15:40Z","timestamp":1759767340000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202300550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,19]]},"references-count":48,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/adhm.202300550"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202300550","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,19]]},"assertion":[{"value":"2023-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300550"}}