{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:38:18Z","timestamp":1792571898311,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23H300003"],"award-info":[{"award-number":["LY23H300003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["ZY2019007"],"award-info":[{"award-number":["ZY2019007"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is the overdosed acetaminophen (APAP), which is metabolized into\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010p\u2010benzoquinone imine (NAPQI), an excessive toxic metabolite, by CYP2E1, resulting in excessive reactive oxygen species (ROS), exhausted glutathione (GSH), and thereafter hepatocyte necrosis.\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine is the Food and Drug Administration\u2010approved drug for detoxification of APAP, but it has limited clinical application due to the short therapeutic time window and concentration\u2010related adverse effects. In this study, a carrier\u2010free and bilirubin dotted nanoparticle (B\/BG@N) is developed, which is formed using bilirubin and 18\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010Glycyrrhetinic acid, and bovine serum albumin (BSA) is then adsorbed to mimic the in vivo behavior of the conjugated bilirubin for hitchhiking. The results demonstrate that B\/BG@N can effectively reduce the production of NAPQI as well as\u00a0exhibit antioxidant effects against intracellular oxidative stress via regulating the nuclear factor erythroid 2\u2010related factor 2\/heme oxygenase\u20101 signal axis and reducing the production of inflammatory factors. In vivo study shows that B\/BG@N can effectively improve the clinical symptom of the mice model. This study suggests that B\/BG@N own increases circulation half\u2010life, improves accumulation in the liver, and dual detoxification, providing a promising strategy for clinical ALF treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300571","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T19:43:51Z","timestamp":1685130231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS"],"prefix":"10.1002","volume":"12","author":[{"given":"Qing","family":"Yao","sequence":"first","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou 325035 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Tang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Huang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Sun","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitianhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou 325035 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Lu","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuyue","family":"Sun","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huirong","family":"Huang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou 325035 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Yao","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Zhejiang Pharmaceutical University  Ningbo 315100 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Lin","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-4279","authenticated-orcid":false,"given":"Longfa","family":"Kou","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"Key Laboratory of Structural Malformations in Children of Zhejiang Province  Wenzhou 325027 P. R. China"},{"name":"Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology  Wenzhou 325000 P. R. China"},{"name":"Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology  Wenzhou 325027 P. R. China"},{"name":"Zhejiang\u2010Hong Kong Precision Theranostics of Thoracic Tumors Joint Laboratory  Wenzhou 325000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 325027 P. R. China"},{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou 325035 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22177"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208937"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902996"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21926"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31894-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00663-0_12"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.04.019"},{"key":"e_1_2_8_8_1","first-page":"331","volume":"3","author":"Krenkel O.","year":"2014","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62062-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158221"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO00953B"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00782"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2021.11.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.06.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133956"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.037"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-020-00550-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120573"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108348"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100925"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.04.021"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122014"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420986711"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102391"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.054"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029864"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120986"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0462-9"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b18986"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002882"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104256"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.12.047"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00907"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.03.034"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.04.033"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47682"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1964543"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.03.013"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21660"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2022.02.003"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139445"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c03564"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0383-9"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500190q"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.936096"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1798979"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22081240"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.08.037"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154162"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128984"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.800169"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.06.013"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.269"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0344-3"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05679"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-21"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202300571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:15:49Z","timestamp":1759767349000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202300571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":57,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/adhm.202300571"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202300571","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]},"assertion":[{"value":"2023-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300571"}}