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Previous studies have found that rapamycin (RAPA) can inhibit fatty infiltration. However, systemic administration of RAPA may cause complications such as infection and nausea, while local administration of RAPA may lead to the cytotoxicity of tendon cells, affecting the healing of rotator cuffs. In this study, biocompatible and clinically approved polycaprolactone\u2010polyethylene glycol (PCL\u2010PEG) is formulated into an injectable nanoparticle for the sustained release of RAPA. The results indicate that the RAPA\/PCL\u2010PEG nanoparticles (NPs) can efficiently prolong the release of RAPA and significantly reduce the cytotoxicity of tendon cells caused by RAPA. The\u00a0study of the fatty infiltration model in rats with delayed rotator cuff repair shows that weekly intraarticular injection of RAPA\/PCL\u2010PEG NPs can more effectively reduce the fatty infiltration and muscle atrophy of rat rotator cuffs and leads to better mechanical properties and gait improvements than a daily intraarticular injection of RAPA. These findings imply that local injection of RAPA\/PCL\u2010PEG NPs in the shoulder joints can be a potential clinical option for RCTs patients with fatty infiltration.<\/jats:p>","DOI":"10.1002\/adhm.202300612","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T19:24:22Z","timestamp":1699298662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Local Injection of Rapamycin\u2010Loaded Pcl\u2010Peg Nanoparticles for Enhanced Tendon Healing in Rotator Cuff Tears via Simultaneously Reducing Fatty Infiltration and Drug Toxicity"],"prefix":"10.1002","volume":"13","author":[{"given":"Jichao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou 510120 P. R. 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