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Inspired by the water absorption and cross\u2010sectional microstructure of sea cucumbers, in this study, a new sea cucumber\u2010like aerogel (GCG) is proposed. Its aligned porous structure and composition can stop bleeding rapidly and effectively with a blood clotting index of 3.73 \u00b1 1.8%. More importantly, the data of in vivo hemostasis test in an amputating rat tail hemostatic model (15.69 \u00b1 2.45 s, 26.95 \u00b1 8.43\u00a0mg) and liver puncture bleeding model (23.77 \u00b1 2.68 s, 36.22 \u00b1 16.92\u00a0mg) also indicate the excellent hemostatic performance of GCG. In addition, GCG also shows a significant inhibitory effect on\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , which can prevent the occurrence of postoperative osteomyelitis. Not only that, after filling\u00a0in the bone defect, it is shown that this GCG aerogel completely degrades eight weeks after surgery and induces new bone ingrowth, achieving functional regeneration after hemostasis of an open fracture defect. Generally, because of its combination of hemostatic, antibacterial, and osteogenic activities, this new aerogel is a promising option for open fractures treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300817","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T02:44:58Z","timestamp":1687315498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sea Cucumber\u2010Inspired Aerogel for Ultrafast Hemostasis of Open Fracture"],"prefix":"10.1002","volume":"12","author":[{"given":"Xinyu","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthopeadic Surgery Affiliated Hospital of Nantong University Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopeadic Surgery Affiliated Hospital of Nantong University Nantong 226001 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