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In this study, the in vivo activity of chrysomycin A (CA) is explored, and a transdermal liposomal CA formulation is further constructed for the simultaneous treatment of cutaneous melanoma and cutaneous methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) infection. The prepared liposomes (TD\u2010LP\u2010CA) display a strong antitumor effect with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of less than 0.1\u00a0\u00b5\n                    <jats:sc>m<\/jats:sc>\n                    in B16\u2010F10 cells, suppress the proliferation of MRSA with a minimum inhibitory concentration (MIC) of 1\u00a0\u00b5\n                    <jats:sc>m<\/jats:sc>\n                    , and eradicate established MRSA biofilms at 10\u00d7 MIC in vitro. More importantly, TD\u2010LP\u2010CA shows enhanced stratum corneum (SC) penetration, reaching more than 500\u00a0\u00b5m beneath the skin's surface due to modification with the TD peptide, and demonstrates excellent subcutaneous tumor penetration after skin application in vivo. TD\u2010LP\u2010CA displays an excellent therapeutic effect against intradermal MRSA infection in mice after topical dermal administration, as well as a moderate inhibitory effect on subcutaneous melanoma with a 75% tumor inhibition rate. The liposomes prepared herein can be a promising carrier for transcutaneous CA transfer for the treatment of superficial diseases such as skin tumors and infections due to their ability to overcome the skin barrier.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300881","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T17:29:46Z","timestamp":1685726986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Enhanced Transdermal Peptide\u2010Modified Flexible Liposomes for Efficient Percutaneous Delivery of Chrysomycin A to Treat Subcutaneous Melanoma and Intradermal MRSA Infection"],"prefix":"10.1002","volume":"12","author":[{"given":"Yue","family":"Cai","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 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