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As oxidative stress is the key cause of periodontitis in the early periodontal microenvironment, antioxidative therapy has been considered a viable treatment for periodontitis. However, more stable and effective reactive oxygen species (ROS)\u2010scavenging nanomedicines are still highly needed due to the instability of traditional antioxidants. Herein, a new type of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010cysteine (NAC)\u2010derived red fluorescent carbonized polymer dots (CPDs) has been synthesized with excellent biocompatibility, which can serve as an extracellular antioxidant to scavenge ROS effectively. Moreover, NAC\u2010CPDs can promote osteogenic differentiation in human periodontal ligament cells (hPDLCs) under H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    stimulation. In addition, NAC\u2010CPDs are capable of targeted accumulation in alveolar bone in vivo, reducing the level of alveolar bone resorption in periodontitis mice, as well as performing fluorescence imaging in vitro and in vivo. In terms of mechanism, NAC\u2010CPDs may regulate redox homeostasis and promote bone formation in the periodontitis microenvironment by modulating the kelch\u2010like ECH\u2010associated protein l (Keap1)\/nuclear factor erythroid 2\u2010related factor 2 (Nrf2) pathway. This study provides a new strategy for the application of CPDs theranostic nanoplatform for periodontitis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300890","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T09:20:32Z","timestamp":1686129632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["<i>N<\/i>\n                    \u2010Acetyl\u2010\n                    <scp>l<\/scp>\n                    \u2010cysteine\u2010Derived Carbonized Polymer Dots with ROS Scavenging via Keap1\u2010Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Xinchan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Jilin University  Changchun 130021 P. R. 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