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Herein, a cancer cell membrane (CM)\u2010camouflaged and ultrasmall iron oxide nanoparticles (USIO NPs)\u2010loaded polyethylenimine nanogel (NG) system is reported to co\u2010deliver docetaxel (DTX) and CD47 siRNA (siCD47). The prepared co\u2010delivery system exhibits good colloidal stability, biocompatibility, and r\n                    <jats:sub>1<\/jats:sub>\n                    relaxivity (1.35 mM\n                    <jats:sup>\u20101<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and enables redox\u2010responsive release of the loaded DTX in the tumor microenvironment. The NG system realizes homologous targeting delivery of DTX and siCD47 to murine breast cancer cells (4T1 cells) for efficient chemotherapy and gene silencing; thus, inducing immunogenic cell death (ICD) and restoring macrophage phagocytic effect through downregulation of \u201cdon't eat me\u201d signals on cancer cells. Likewise, the co\u2010delivery system can also act on macrophages to promote their M1 polarization, which can be combined with DTX\u2010mediated ICD and antibody\u2010mediated immune checkpoint blockade to generate effector T cells for robust chemoimmunotherapy. Further, the USIO NPs\u2010incorporated NG system also allows for magnetic resonance imaging of tumors. The developed biomimetic NG system acting on both cancer cells and macrophages holds a promising potential for macrophage phagocytosis\u2010restored chemoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300967","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T11:08:49Z","timestamp":1689851329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A Biomimetic Nanogel System Restores Macrophage Phagocytosis for Magnetic Resonance Imaging\u2010Guided Synergistic Chemoimmunotherapy of Breast Cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Lulu","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai 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