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Nevertheless, there are no hemoperfusion adsorbents that can simultaneously remove small and medium toxins, including bilirubin, urea, phosphor, heavy metals, and antibiotics. This bottleneck significantly impedes the miniaturization and portability of hemoperfusion materials and devices. Herein, a biocompatible protein\u2010polysaccharide complex is reported that exhibits \u201cmulti\u2010in\u2010one\u201d removal efficacy for liver and kidney metabolism wastes, toxic metal ions, and antibiotics. Through electrostatic interactions and polysaccharide\u2010mediated coacervation, adsorbents can be prepared by simply mixing lysozyme (LZ) and sodium alginate (SA) together in seconds. The LZ\/SA absorbent presented high adsorption capacities for bilirubin, urea, and Hg\n                    <jats:sup>2+<\/jats:sup>\n                    of up to 468, 331, and 497\u00a0mg\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively, and the excellent anti\u2010protein adsorption endowed LZ\/SA with a record\u2010high adsorption capacity for bilirubin in the interference of serum albumin to simulate the physiological environment. The LZ\/SA adsorbent also has effective adsorption capacity for heavy metals (Pb\n                    <jats:sup>2+<\/jats:sup>\n                    , Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , Cr\n                    <jats:sup>3+<\/jats:sup>\n                    , and Cd\n                    <jats:sup>2+<\/jats:sup>\n                    ) and multiple antibiotics (terramycin, tetracycline, enrofloxacin, norfloxacin, roxithromycin, erythromycin, sulfapyrimidine, and sulfamethoxazole). Various adsorption functional groups exposed on the adsorbent surface significantly contribute to the excellent adsorption capacity. This fully bio\u2010derived protein\/alginate\u2010based hemoperfusion adsorbent has great application prospects in the treatment of blood\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202300999","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T06:05:14Z","timestamp":1687154714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Protein\/Polysaccharide Composite toward Multi\u2010in\u2010One Toxin Removal in Blood with Self\u2010Anticoagulation and Biocompatibility"],"prefix":"10.1002","volume":"12","author":[{"given":"Mengjie","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an 710119 China"},{"name":"Xi'an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Facui","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials and Chemical Engineering Xi'an Technological University  Xi'an 710021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Qin","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &amp; Engineering (IBME) Northwestern Polytechnical University  127 West Youyi Road Xi'an 710072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an 710119 China"},{"name":"Xi'an Key Laboratory of Polymeric Soft Matter School of 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