{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:34:52Z","timestamp":1792010092115,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930119"],"award-info":[{"award-number":["81930119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090053"],"award-info":[{"award-number":["82090053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000484"],"award-info":[{"award-number":["82000484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional tissue adhesives face challenges for hemostasis and tissue regeneration in large\u2010scaled hemorrhage and capillary hypobaric bleeding due to weak adhesion, and inability to degrade at specific sites. Herein, convenient and injectable poly(ethylene glycol) (PEG)\u2010based adhesives are developed to address the issues for liver hemostasis. The PEG\u2010bioadhesives are composed of tetra\u2010armed PEG succinimide glutarate (PEG\u2010SG), tetra\u2010armed PEG amine (PEG\u2010NH<jats:sub>2<\/jats:sub>), and tri\u2010lysine. By mixing the components, the PEG\u2010bioadhesives can be rapidly formulated for use of liver bleeding closure in hepatectomy. The PEG\u2010bioadhesives also possess mechanical compliance to native tissues (elastic modulus \u224840\u00a0kPa) and tough tissue adhesion (\u224828\u00a0kPa), which enables sufficient adhering to the injured tissues and promotes liver regeneration with the PEG\u2010bioadhesive degradation. In both rats of liver injury and pigs of large\u2010scaled hepatic hemorrhage, the PEG\u2010bioadhesives show effective hemostasis with superior blood loss than conventional tissue adhesives. Due to biocompatibility and degradability, the PEG\u2010bioadhesive is advantageous for liver regeneration, while commercial adhesives (e.g., <jats:italic>N<\/jats:italic>\u2010octyl cyanoacrylate) display adhesion failure and limited liver reconstructions. These PEG\u2010bioadhesive components are FDA\u2010approved, and demonstrate excellent adhesion to various tissues not only for liver hemostasis, it is a promising candidate in biomedical translations and clinical applications.<\/jats:p>","DOI":"10.1002\/adhm.202301086","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T08:45:11Z","timestamp":1688805911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Highly Tough and Biodegradable Poly(ethylene glycol)\u2010Based Bioadhesives for Large\u2010Scaled Liver Injury Hemostasis and Tissue Regeneration"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-4546","authenticated-orcid":false,"given":"Yiqian","family":"Huang","sequence":"first","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jing","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing 102218 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Xue","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd  Beijing 102600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Dong","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing 102218 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000288"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2009.05.006"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00926"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.111281"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.8.JNS191592"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03575-0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600830432"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.08.043"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2007.9960"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.103019"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01463-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.03.019"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b04017"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901580"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101809"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202200908"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101467"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00798"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2021.151717"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.12.072"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.02.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b12317"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116051"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857096425.4.449"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1710-5"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c01022"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.08.023"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202109332"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202207306"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00144"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01467-y"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0171-7"},{"key":"e_1_2_8_16_3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117002043"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-020-00585-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00323-z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.06.020"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2018.09.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24104-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12429-6"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202301086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:43:11Z","timestamp":1759765391000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202301086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":39,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/adhm.202301086"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202301086","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2301086"}}