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However, clinics still lack high\u2010throughput, low\u2010invasive, precise, and objective diagnostic strategies. Herein, the Au nanoparticles anchored porous perovskite oxide microrods (CTO@Au) with designed superior properties is developed to construct a high\u2010throughput detection platform. Specifically, a single metabolic fingerprinting is obtained from only 30 nL of serum within seconds, enabling the rapid acquisition of 239\u00a0\u00d7 8 high\u2010quality fingerprints in \u2248 2 h. AD is distinguish from health controls and Parkinson's disease with an area under the curve (AUC) of 1.000. Moreover, eight specific metabolites are identified as a biomarker panel, based on which precise diagnosis of AD is achieved, with an AUC of 1.000 in blind test. The possible relevant pathways and potential mechanism involved in these biomarkers are investigated and discussed. This work provides a high\u2010performance platform for metabolic diagnostic analysis.<\/jats:p>","DOI":"10.1002\/adhm.202301136","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T08:47:10Z","timestamp":1689324430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Construction of Porous Perovskite Oxide Microrods with Au Nanoparticle Anchor for Precise Metabolic Diagnosis of Alzheimer's Disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Heyuhan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry Department of Institutes of Biomedical Sciences Zhongshan Hospital Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Institutes of Biomedical Sciences Zhongshan Hospital Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Materials Science and Chemical Engineering Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8704-7543","authenticated-orcid":false,"given":"Chunhui","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Institutes of Biomedical Sciences Zhongshan Hospital Fudan University  Shanghai 200433 China"},{"name":"School of Chemistry and Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianrong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05243-7"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00153-2"},{"key":"e_1_2_8_2_1","first-page":"1851","volume":"320","author":"Kuehn B.","year":"2018","journal-title":"J. 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