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Translational research regarding meniscus regeneration is hindered by the complex, composite nature of the meniscus which exhibit a gradient from inner cartilage\u2010like tissue to outer fibrous tissue, as well as engineering hurdles often requiring growth factors and cross\u2010linking agents. Here, a meniscus zonal tissue gradient is proposed using zone\u2010specific decellularized meniscus extracellular matrix (DMECM) and autologous synovial mesenchymal stem cells (SMSC) via self\u2010aggregation without the use of growth factors or cross\u2010linking agents. Combination with zone\u2010specific DMECM during self\u2010aggregation of MSCs forms zone\u2010specific meniscus tissue that reflects the respective DMECM harvest site. The implantation of these constructs leads to the regeneration of meniscus tissue resembling the native meniscus, demonstrating inner cartilaginous and outer fibrous characteristics as well as recovery of native meniscal microarchitecture in a porcine partial meniscectomy model at 6 months. In all, the findings offer a potential regenerative therapy for DMTs that may improve current partial meniscectomy\u2010based patient care.<\/jats:p>","DOI":"10.1002\/adhm.202301180","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T18:19:41Z","timestamp":1689704381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Selective Extracellular Matrix Guided Mesenchymal Stem Cell Self\u2010Aggregate Engineering for Replication of Meniscal Zonal Tissue Gradient in a Porcine Meniscectomy Model"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-2683","authenticated-orcid":false,"given":"Sujin","family":"Noh","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Graduate School of Ajou University  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Jun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine Ajou University  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Molecular Science and Technology Ajou University  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Jae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Molecular Science and Technology Ajou University  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Woong","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine Ajou University  Suwon 16499 Republic of Korea"},{"name":"Cell Therapy Center Ajou Medical Center  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Cell Therapy Center Ajou Medical Center  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Surgery CHA University Bundang Medical Center  Bundang\u2010gu Seongnam\u2010si Gyeonggi\u2010do 13496 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine Ajou University  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-6684","authenticated-orcid":false,"given":"Do Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Graduate School of Ajou University  Suwon 16499 Republic of Korea"},{"name":"Department of Orthopedic Surgery School of Medicine Ajou University  Suwon 16499 Republic of Korea"},{"name":"Cell Therapy Center Ajou Medical Center  Suwon 16499 Republic of Korea"},{"name":"Ajou University, Leading Convergence of Healthcare and Medicine, Institute of Science &amp; Technology (ALCHeMIST)  Suwon 16499 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800777"},{"key":"e_1_2_9_2_1","first-page":"19294964","volume-title":"Ambulatory Surgery in the United States","author":"Cullen K. 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