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However, scalable technologies that allow continuous, multiparametric monitoring for identifying metastasis inhibitors are absent. Here, the development of a functional phenotypic screening platform based on organic electrochemical transistors (OECTs) for real\u2010time, noninvasive monitoring of TEV\u2010induced EMT and screening of antimetastatic drugs is reported. TEVs derived from the triple\u2010negative breast cancer cell line MDA\u2010MB\u2010231 induce EMT in nonmalignant breast epithelial cells (MCF10A) over a nine\u2010day period, recapitulating a model of invasive ductal carcinoma metastasis. Immunoblot analysis and immunofluorescence imaging confirm the EMT status of TEV\u2010treated cells, while dual optical and electrical readouts of cell phenotype are obtained using OECTs. Further, heparin, a competitive inhibitor of cell surface receptors, is identified as an effective blocker of TEV\u2010induced EMT. Together, these results demonstrate the utility of the platform for TEV\u2010targeted drug discovery, allowing for facile modeling of the transient drug response using electrical measurements, and provide proof of concept that inhibitors of TEV function have potential as antimetastatic drug candidates.<\/jats:p>","DOI":"10.1002\/adhm.202301194","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T10:49:44Z","timestamp":1683888584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Organic Electronic Platform for Real\u2010Time Phenotypic Screening of Extracellular\u2010Vesicle\u2010Driven Breast Cancer Metastasis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-2253","authenticated-orcid":false,"given":"Walther C.","family":"Traberg","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology University of Cambridge  Cambridge CB3 0AS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Uribe","sequence":"additional","affiliation":[{"name":"Robert F. 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