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Understanding its molecular mechanisms is the basis for developing specific treatment. To demonstrate that miR\u201022\u20103p is critical in the regulation of IDD, miRNA microarray analyses are conducted in conjunction with in vivo and in vitro experiments. The miR\u201022\u20103p knockout (KO) mice show a marked decrease in the histological scores. Bioinformatic analysis reveals that miR\u201022\u20103p plays a mechanistic role in the development of IDD by targeting SIRT1, which in turn activates the JAK1\/STAT3 signaling pathway. This is confirmed by a luciferase reporter assay and western blot analysis. Therapeutically, the delivery of miR\u201022\u20103p inhibitors and mimics through the synthesized nanoparticles in the IDD model alleviates and aggravates IDD, respectively. The nanocarriers enhance transportation of miR\u201022\u20103p to nucleus pulposus cells, thus enabling the in vivo inhibition of miR\u201022\u20103p for therapeutic purposes and consequently promoting the development of miRNA\u2010specific drugs for IDD.<\/jats:p>","DOI":"10.1002\/adhm.202301337","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:34:32Z","timestamp":1692984872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nucleus Pulposus\u2010Targeting Nanocarriers Facilitate Mirna\u2010Based Therapeutics for Intervertebral Disc Degeneration"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhonghui","family":"Chen","sequence":"first","affiliation":[{"name":"Orthopaedic Surgery Fujian Medical University Union Hospital  Fuzhou Fujian 350000 China"},{"name":"Orthopaedic Surgery Fuzhou Second Hospital  Fuzhou Fujian 350000 China"},{"name":"Orthopaedic Surgery Renmin Hospital of Wuhan University  Wuhan Hubei 430000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liao","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery Fujian Medical University Union Hospital  Fuzhou Fujian 350000 China"},{"name":"Orthopaedic Surgery Fuzhou Second Hospital  Fuzhou Fujian 350000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; 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