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It can lead to severe abdominal infection and abdominal adhesions, resulting in prolonged hospital stays and increased mortality. In this study, a photosensitive hydrogel is proposed, which can swiftly form a strong adhesion coating on the damaged colon after UV irradiation, to realize quick cure and suture\u2010free repair of colon leakage. The newly developed biological gel consists of hyaluronic acid methacryloyl (HAMA) and hyaluronic acid o\u2010nitroso benzaldehyde (HANB) in the optimal ratio of 3: 1, which exerts both the rapid photocuring properties of HAMA and the strong tissue adhesion properties of HANB. HAMA\/HANB shows excellent adhesion stability on wet surfaces, presenting controllable mechanical properties, ductility, adhesion stability, and chemical stability; it also evades foreign body response, which relieves the degree of abdominal adhesion. The underlying mechanism for HAMA\/HANB promoting wound healing in colon leakage involves the reconstruction of the colon barrier, as well as the regulation of the immune reaction and neovascularization. In all, HAMA\/HANB is a promising alternative suture\u2010free approach for repairing colon leakage; it has a reliable healing effect and is expected to be extended to clinical application for other organ injuries.<\/jats:p>","DOI":"10.1002\/adhm.202301379","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:30:18Z","timestamp":1690979418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Strong Adhesive Biological Hydrogel for Colon Leakage Repair and Abdominal Adhesion Prevention"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-7385","authenticated-orcid":false,"given":"Qijiang","family":"Mao","sequence":"first","affiliation":[{"name":"Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengze","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hangzhou Fuyang Hospital of Traditional Chinese Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hong","sequence":"additional","affiliation":[{"name":"Dr. Li Dak Sum &amp; 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