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Herein, a biomimetic nanoplatform (AU\u2010LIP\u2010CM) comprising Au cluster enzymes (AU)\u2010loaded liposomes (AU\u2010LIP) camouflaged with the fusion membrane (CM) consisting of neutrophil (NC) and red blood cell (RBC) membrane is designed for the treatment of UC. Briefly, revealed by second near\u2010infrared (NIR\u2010II) imaging through collection of fluorescence emitting &gt;1200 nm from AU, the improved inflammatory targeting behavior contributed by CM cloaking, which inherits abilities of inflammatory targeting and immune escape from NC and RBC, respectively, promotes specific accumulation of AU within inflammatory intestines with up to \u224811.5 times higher than that of bare AU. Afterward, AU possessing superoxide dismutase\u2010 and catalase\u2010like activities realizes high\u2010efficiency scavenging of reactive oxygen species (ROS), leading to repair of intestinal barriers, regulation of the immune system, and modulation of gut microbiota, which surpass first\u2010line UC drug. In addition, study of underlying therapeutic mechanism demonstrated that the treatment with AU\u2010LIP\u2010CM can alter the gene signature associated with response to ROS for UC mice to a profile similar to that of healthy mice, deciphering related signal pathways. The strategy developed here provides insights of learning from properties of natural bio\u2010substances to empower biomimetic nanoplatform to confront diseases.<\/jats:p>","DOI":"10.1002\/adhm.202301450","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T01:41:07Z","timestamp":1691113267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Biomimetic Nanoplatform with Improved Inflammatory Targeting Behavior for ROS Scavenging\u2010Based Treatment of Ulcerative Colitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaofen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Physics and Tianjin Key Laboratory of Low Dimensional 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