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A clinically viable biomaterial that enhances cell retention can optimize intramyocardial cell delivery. In this study, a therapeutic cell delivery method is developed for MI treatment utilizing a photocrosslinkable gelatin methacryloyl (GelMA) hydrogel. Human vascular progenitor cells, capable of forming functional vasculatures upon transplantation, are combined with an in situ photopolymerization approach and injected into the infarcted zones of mouse hearts. This strategy substantially improves acute cell retention and promotes\u00a0long\u2010term post\u2010MI cardiac healing, including stabilized cardiac functions, preserved viable myocardium, and reduced cardiac fibrosis. Additionally, engrafted vascular cells polarize recruited bone marrow\u2010derived neutrophils toward a non\u2010inflammatory phenotype via transforming growth factor beta (TGF\u03b2) signaling, fostering a pro\u2010regenerative microenvironment. Neutrophil depletion negates the therapeutic benefits generated by cell delivery in ischemic hearts, highlighting the essential role of non\u2010inflammatory, pro\u2010regenerative neutrophils in cardiac remodeling. In conclusion, this GelMA hydrogel\u2010based intramyocardial vascular cell delivery approach holds promise for enhancing the treatment of acute myocardial infarction.<\/jats:p>","DOI":"10.1002\/adhm.202301581","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T17:50:40Z","timestamp":1692813040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Photopolymerizable Hydrogel for Enhanced Intramyocardial Vascular Progenitor Cell Delivery and Post\u2010Myocardial Infarction Healing"],"prefix":"10.1002","volume":"12","author":[{"given":"Xuechong","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Surgery Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen Chilun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Doulamis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Surgery Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Surgery Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang\u2010Bum","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Surgery Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas M. 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